Acemannan: The New Polysaccharide in Cosmetics

Acemannan: The New Polysaccharide in Cosmetics What is Acemannan and How Does It Differ from Other Sugars? Acemannan is a sugar found in the inner gel of the Aloe vera plant. It is composed of long chains of mannose polysaccharides (sugars), with some glucose and galactose molecules also present. Acemannan is known for its potential health benefits, which include immune system modulation, wound healing, and anti-inflammatory effects. One key difference between acemannan and other sugars is its chemical structure and molecular weight. Its molecular weight (MW) can range from 400 to 1200 KDa, depending on the source and extraction method. Acemannan's molecular weight falls within the range of other complex sugars, such as hyaluronic acid, which have been shown to penetrate the stratum corneum of the skin. Therefore, acemannan could penetrate the stratum corneum more effectively than other sugars. Another important difference is the source of acemannan. Unlike many other sugars, which are commonly extracted from corn, sugar cane, or other plants, acemannan is unique to the Aloe vera plant.

Why Should Acemannan Be Used in Cosmetics Based on Its Properties?

Acemannan offers a variety of potential benefits when used in cosmetic formulations. Here are some of the benefits that acemannan may provide: Moisturizing: Acemannan has been shown to help retain moisture in the skin, which can help to prevent dryness and flakiness. This can be particularly beneficial for individuals with dry or sensitive skin. Anti-inflammatory: Acemannan has been shown to have anti-inflammatory properties, which can help to reduce redness and itching in the skin. This makes it potentially useful for calming irritated or inflamed skin. Structural Repair: Acemannan has been shown to promote structural repair by stimulating the production of collagen, which is important for maintaining the structure and elasticity of the skin.

How Did Active Bioworks Isolate This Product Using Unique Methods?

Active Bioworks sources aloe vera plants from local farmers who cultivate aloe vera and ferments them with a special mixture of bacteria and fungi. These microorganisms are selected according to their special enzymes to create more accessible and pure acemannan. This process involves enzyme treatment and is called BETA™ (Bacterial Extraction Targeting Actives) Technology. The mixture then undergoes purification, and the acemannan-rich gel is dried. Thus, pure acemannan is obtained without damage and at low molecular weight.

Efficacy Tests of Active Bioworks' Acemannan-Rich Product Hydractive 100®

Acemannan has a mechanism of action involving cyclin D-1, a protein that is involved in cell cycle regulation. Here is a simple explanation of how acemannan interacts with cyclin D-1:   Cyclin D-1 is a protein that helps to regulate the cell cycle by controlling the progression of cells from the G1 phase to the S phase, where DNA synthesis occurs. In healthy cells, cyclin D-1 is tightly regulated, and its expression is controlled by a variety of signaling pathways. Acemannan is one of the signal molecules that triggers expression of cyclin D-1. Thus, it helps cells to remain healthy. In vitro studies of HydrActive 100® have shown that acemannan can interact with cyclin D-1 and increase its expression by up to 2.7 fold. This produces effects on the skin, including increased cell proliferation and enhanced collagen synthesis. By increasing the amount of collagen in the skin, the skin will become stronger, more elastic, and better able to retain moisture. This can lead to a more hydrated, plump, and youthful-looking complexion. Additionally, acemannan in HydrActive 100® has a synergistic prebiotic effect with other ingredients. Prebiotic means that it provides nourishment for the beneficial bacteria that naturally live on the skin. These bacteria, also known as the skin microbiome, play an important role in maintaining the health and function of the skin. A healthy microbiome is essential for maintaining the overall health and appearance of the skin. The beneficial bacteria in the microbiome can help to prevent infections, reduce inflammation, and improve skin hydration. Low molecular weight sugars are a great source for skin microbiome growth. Here is the growth analysis of skin microbiome bacteria S. epidermidis:     In vitro studies of HydrActive 100® showed growth-promoting activity up to 38% on standard S. epidermidis strain (ATCC 12228). The growth-promoting effects of S. epidermidis on the skin are beneficial for maintaining healthy skin and preventing various skin conditions. M. Selim Yılmaz Head of Biology Active Bioworks