The conventional silicon dioxide is used as a flow-enhancer or adsorption carrier due to its inertness (the pH is neutral when it is water suspension.) It may however impede tablet hardness or complicate the powder handling due to its lack of compressibility and flowability.
FujiSil has been developed with Fuji’s proprietary method, and it has overcome all the shortcomings of the conventional silicate. FujiSil’s numerous pores enables the high absorption capacity due to its large specific surface area.
Comparison of Tablet Hardness Among FujiSilTM and Other SiO2
Conventional silicon dioxide causes the decrease in the tablet hardness. However, FujiSilTM shows no such signs.
Application in Taste Masking Granules
FujiSilTM is also a spherical adsorption carrier with a superb flow. It can be used as an inert core to create smaller taste masking granules than conventional carriers. In addition, it can shorten the granulation time compared to other inert cores.
Application in Moisture Protection
FujiSilTM is helpful for the moisture protection of hygroscopic API due to it is high moisture adsorption property. FujiSilTM helps to increase the stability of such moisture sensitive and hygroscopic drugs.
Application in Solid Dispersion
Turning poorly-soluble APIs into an amorphous state can improve the solubility. FujiSilTM is porous inorganic excipient and can be used as a carrier to stabilize the amorphous state. The solid dispersion prepared using spray drying method, it also has a superior flowability and aid the subsequent processing.
Pharmacopoeia & Regulatory
FujiSilTM is listed in USP/NF(as Silicon Dioxide,) EP (as Silica Colloidal Hydrated,) and JPE. Filing of US DMF Type IV is also under way.
Properties of FujiSilTM-F
FujiSilTM-F is an excipient for dietary supplement. It retains the high adsorption, flowability and superior compressibility of the FujiSil family of excipients.
FujiSilTM-F as an Oil Adsorption Carrier
FujiSilTM-F has a high oil absorption value, and suited for absorption carrier. Also, the spherical granule demonstrates splendid flowability.
FujiSilTM-F as an Oil Adsorption Carrier
FujiSilTM-F has a high oil absorption value, and suited for absorption carrier. Also, the spherical granule demonstrates splendid flowability.
Application in Moisture Protection
FujiSilTM-F can protect hygroscopic and moisture sensitive herbalextract from moisture sensitive herbal extract from moisture.
Safety Information
FujiSilTM-F is amorphous. BSE/TSE, Non-GMO, allergen free statements are issued upon request. FujiSilTM-F does not contain any residual organic solvent
Solid Dispersion Application of Neusilin® , Fujicalin® and FujiSilTM
Turning the active into an amorphous state is one method to improve the solubility of poorly soluble API. Neusilin® and Fujicalin ®, which are porous inorganic excipients, can stabilize the amorphous state of APIs. They can be used as an inert carrier to prepare amorphous solid dispersion via spray drying (SD) or hot melt extrusion (HME)
FujiSilTM-F Features
• Versatile excipient due to its high compressibility and superior flowability.
• Helps to minimize hardness drop during high humidity storage due to its.
• Very high moisture adsorption property.
• Promotes disintegration of tablets due to its water induction characteristics.
• It maintains high flowability even after adsorption.
• Can be used as a carrier for taste masking granules and solid dispersion application in moisture protection for hygroscopic and moisture sensitive drugs.
• Versatile excipient due to its inertness and superb flowability.
• High absorption value and enables powderization of oily ingredients.
• Oil absorbed FujiSilTM -F maintains the exceptional flowability due to its spherical shape.
• FujiSilTM -F prevents seeping of oily ingredients upon tableting when used as the carrier.
• Application in moisture protection for hygroscopic and moisture sensitive herbal extract.
