Acemannan : The New Polysaccharide in Cosmetics
What is Acemannan and Difference from Other Sugars?
Acemannan is a sugar that is found in the inner gel of the Aloe vera plant. It is composed of long chains of mannose polysaccharides (sugars), with some glucose and galactose molecules also present.
Acemannan is known for its potential health benefits, which include immune system modulation, wound healing, and anti-inflammatory effects.
One key difference between acemannan and other sugars is its chemical structure and molecular weight. Its molecular weight (MW) can range from 400 to 1200 KDa, depending on the source and extraction method.
Acemannan’s molecular weight falls within the range of other complex sugars, such as hyaluronic acid, which have been shown to penetrate the stratum corneum of the skin.
So acemannan could be more penetrate than other sugars into stratum corneum. Another important difference is the source of acemannan. Unlike many other sugars, which are commonly extracted from corn, sugar cane, or other plants, acemannan is unique to the
Aloe vera plant.
Due to Which Properties it Provides in Cosmetics Should It Be Used?
Acemannan that has a variety of potential benefits when used in cosmetic formulations. Here are some of the benefits that acemannan may provide:
Moisturizing: Acemannan has been shown to help retain moisture in the skin, which can help to prevent dryness and flakiness. This can be particularly beneficial for individuals with dry or sensitive skin.
Anti-inflammatory: Acemannan has been shown to have anti-inflammatory properties, which can help to reduce redness and itching in the skin. This makes it potentially useful for calming irritated or inflamed skin.
Structural Repair: Acemannan has been shown to promote structural repair by stimulating the production of collagen, which is important for maintaining the structure and elasticity of the skin.
How Did Active Bioworks Isolate This Product with Unique Methods?
Active Bioworks provides aloe vera plants from local farmers who cultivate aloe vera and fermented with special mixture of bacteria and fungus combines.
These microorganisms are selected according to their special enzymes to create more accessible and pure acemannan. This process is enzyme treatment and called BETA™ (Bacterial Extraction Targeting Actives) Technology.
Then the mix is going to purification step and acemannan rich gel is dried. Thus, pure acemannan is obtained without damage and in low molecular weight.
Active Bioworks Acemannan-Rich Product Hydractive 100® Efficacy Tests
Acemannan have a mechanism of action involving cyclin D-1, a protein that is involved in cell cycle regulation. Here is a simple explanation of how acemannan interacts with cyclin D-1:
Cyclin D-1 is a protein that helps to regulate the cell cycle by controlling the progression
of cells from the G1 phase to the S phase, where DNA synthesis occurs.
In healthy cells, cyclin D-1 is tightly regulated, and its expression is controlled by a variety of signaling pathways. Acemannan is one the signal molecules that triggers expression of
Cyclin D-1. So, it is help to cells to be healthy.
In vitro study of HydrActive 100® have shown that Acemannan can interact with cyclin D-1 and increase its expression as up to 2.7 fold. This will have effects on the skin, including; increased cell proliferation and enhanced collagen synthesis.
By increasing the amount of collagen in the skin, the skin will become stronger, more elastic, and better able to retain moisture. This can lead to a more hydrated, plump, and
youthful-looking complexion.
Also Acemannan in HydrActive 100® have synergistic prebiotic effect with the other content. Prebiotic, which means that it provides food for the beneficial bacteria that naturally live on the skin. These bacteria, also known as the skin microbiome, play an
important role in maintaining the health and function of the skin.
A healthy microbiome is essential for maintaining the overall health and appearance of the
skin. The beneficial bacteria in the microbiome can help to prevent infections, reduce inflammation, and improve skin hydration.
Low molecular weight sugars great source for skin microbiome growth. Here is the growth analysis of skin microbiome bacteria S. epidermidis:
In vitro study of HydrActive 100® showed growth promoting activity up to 38% on standard S. epidermidis strain (ATCC 12228). The growth-promoting effects of S. epidermidis on the skin are beneficial for maintaining healthy skin and preventing various skin conditions.
M. Selim Yılmaz
Head of Biology
Active Bioworks
