A New Class of Cosmetic Actives: Miniprotein
Continuous operation of mimic muscles causes skin folds to be visible; Line formation is observed in the face area over time. Decades of experience in aesthetic
medicine have identified the key role of relaxation of facial muscles in the treatment and prevention of
wrinkles. Relaxing the muscles under the skin quickly reduces wrinkles and improves facial appearance in the long run.
Activen, headquartered in Switzerland; searches the genomic sequences of living organisms to discover high-performance actives. It is a MiniproteinTM generator
containing a range of monopeptides between protein and peptides using bioinformatics.
Although these miniproteins have a 3D molecular structure; They are proteins that are small enough to penetrate the skin and offer high and specific efficacy on a specific target. Their actives are highly potent and safe, which makes them a unique choice among nextgeneration active ingredients. Activen XEP®-018 is a muscle relaxant miniprotein™ naturally found in the venom of the Pacific Ocean sea snail Conus consors.
Activen XEP 018 Miniprotein: Developed with the concept of “Botox in Jar” with the bioinformatics method. This protein, which is based on a muscle relaxation mechanism and has a 3D molecular structure, is a polypeptide structure located between Botox and peptides in linear structure and within 20 peptides.
Miniproteins containing 22 amino acids are nonlinear structures in size between peptide structures and protein structures. While the peptide containing 20 amino acids is as small as its molecular structure, it penetrates the skin; Since it is much smaller than the protein structures, it does not have to apply injectables.
• Peptides can be broken down by protease enzymes after absorption due to their less amino acid content, but Activen miniproteins are not broken down. Comparison tests have been conducted with trademarked peptides and their efficacy is 500% higher. This structure is due to the 3D and complex molecular structure (peptides are linear).
• Due to its 3D (three-dimensional) molecular structure, the receptor binds directly to the molecule. Peptides have no such ability, only excitation activities.
• Unlike Botox, it creates wrinkles naturally without the mimic lines disappearing and does not give a monotonous appearance.
Although Botox affects the nerve endings and the long-term damage is not yet clear, it is an issue that should be approached with a little distance. Activen miniprotein, on the other
hand, blocks the sodium channels in the nerve endings and prevents the sodium passages, thus relaxing the muscles and creating wrinkles, thus avoiding the harmful effects of Botox.
It shows its effect within 2 hours and the effect continues for 24 hours. In 28 days of use, it shows a cumulative effect and shows a very significant effect on wrinkles.
In conclusion;
Activen XEP 018 miniprotein structure, the effect of which has been supported by clinical studies; Considering the benefits such as being 500% more effective than trademarked peptides, being resistant to degradation by protease enzymes, providing good penetration
with its 3D structure and preventing nerve and tissue damage that may occur in botox application, it has a high potential for use in new generation applications.
In this context, using Activen, successful applications can be realized in the cosmetic ingredient market, in the fields of anti-aging and regenerative dermatology, neuro-dermatology and immunodermatology.
Şerife Dedeli
Sales Engineer
Profen Life Sciences
